Shreya Tapaswi

DC01: Molecular mechanisms involved in the degradation processes of damaged mitochondrial messenger RNAs
About me

As a dedicated bio-enthusiast, I have always been captivated by the realm of life science research. Taking a year’s gap after high school, I embarked on an immersive exploration of this field. Engaging in online courses on molecular biology, biochemistry, and more, I also underwent training in biology research at Presidency University in Kolkata, my hometown. These experiences solidified my passion for scientific inquiry and confirmed my desire to pursue a career as a researcher.

Pursuing a BSc in Biotechnology at Manipal University, I undertook two summer internships. The first focused on lipid droplets and image processing at the Indian Association for the Cultivation of Science. The second, as part of the Indian Academy of Sciences Summer Research Fellowship Programme, involved molecular genetics of primary congenital glaucoma.

For my BSc project, I worked on cloning, expression, and purification of the p53R2 protein. Pursuing an MSc in Biochemistry at Ruhr-Universität Bochum, my master’s thesis centred on mitochondrial proteomics.

By gaining expertise in mitochondrial research in MITGEST, I aim to make meaningful contributions to the study of aging and its associated processes. Join me as we unravel the mysteries of mitochondria and advance our understanding of aging through the collaborative network of MITGEST.

About my project

In this project, we will investigate and elucidate the molecular mechanisms, protein partners and kinetics of mitochondrial messenger RNAs (mt-mRNA) degradation processes that are currently unknown. With proteomics-based approaches based on mass spectrometry, we will identify proteins associated with mitochondrial APE1 and damaged mt-mRNAs. We will then investigate their roles and functions by applying biochemical methods.