Mitochondria are receiving increased attention from investigators with varied interests and backgrounds. Novel techniques are now being used to study both mitochondrial structure and functioning, and these methods are leading to a redefining of long-held views about the basic biology of the organelle. The overarching aim of MITGEST is to understand the quality control and homeostasis of mitochondrial DNA and its expression and develop novel approaches and disease intervention/therapy while training a future generation of highly qualified researchers within the time frame of the MITGEST Doctoral Network (DN).
MITGEST research programme
The MITGEST programme is divided into four research and innovation work packages (WPs) with partners that bring complementary expertise required to advance in science and innovation. These WPs include 11 individual research projects to be pursued by our DC next to their transferable skills training.
In this WP, various complementary methods and approaches will be used to study the origin and accumulation of mtDNA abnormalities and the synthesis, stability, and decay pathways of mtRNA in health and disease states (UNIUD, Radboudumc, IBB).
In this WP, the focus is on gaining novel insights into mitochondrial translation, particularly on mitoribosome assembly and functionality and the coordination of nuclear and mitochondrial gene expression (UNIUD, Radboudumc, KI, UCL).
In this WP, we aim to advance our understanding of the pathophysiology of mitochondrial dysfunction by investigating several disease models. We will uncover the ripples and responses and effects of potential therapies (UNIUD, BRI, UCL).
In this WP, we will develop the novel methods needed to drive forward the critical research of mitochondrial gene expression, complementing the effort to identify new therapies for mitochondrial diseases (UNIUD, Radboudumc, BRI, UCL, BASECLICK, MINOVIA).